Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis.

Abstract

Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell culture epidemiological, and clinical studies) and their role in the development of cardiovascular disease.

• Authors: T K Nordt, J Lohrmann, C Bode
• Journal: Thrombosis research (Thromb Res) Vol. 103 Suppl 1 Pg. S1-5 (Sep 30 2001) ISSN: 0049-3848 [Print] United States
• PMID: 11567663 (Publication Type: Journal Article, Review)

Chemical References

• Plasminogen Activator Inhibitor 1
• Serine Proteinase Inhibitors

Topics

• Cardiovascular Diseases (etiology, genetics)
• Gene Expression Regulation (genetics)
• Humans
• Plasminogen Activator Inhibitor 1 (biosynthesis, genetics, physiology)
• Polymorphism, Genetic (physiology)
• Serine Proteinase Inhibitors (biosynthesis, genetics)