Chemical synoviorthesis with osmic acid in haemophilia.

Abstract

Based on previous experience in inflammatory arthritis, a small number of open studies have evaluated the usefulness of chemical synoviorthesis with osmic acid in haemophilia, with various assessment criteria and a wide range of follow-up periods. Based on these studies, the efficacy of osmic acid seems modest, with 30-44% of good clinical and radiological results, but with fair or poor clinical results in other patients with a possible deleterious effect on cartilage. Osmic acid was found inferior to Yttrium-90 in one retrospective study. Synoviorthesis with osmic acid seems particularly indicated in haemophilic arthritis with no or mild radiological deterioration in children between 8 and 15 years of age. However, prospective randomized studies are clearly required to evaluate the symptomatic and structural effects of chemical and radioactive synoviorthesis in haemophilic arthritis.

• Authors: X Ayral
• Journal: Haemophilia : the official journal of the World Federation of Hemophilia (Haemophilia) Vol. 7 Suppl 2 Pg. 20-5 (Jul 2001) ISSN: 1351-8216 [Print] England
• PMID: 11564140 (Publication Type: Journal Article, Review)

Chemical References

• Radioisotopes
• Osmium Tetroxide

Topics

• Age Factors
• Hemarthrosis (complications, drug therapy, etiology)
• Hemophilia A (complications, pathology, therapy)
• Humans
• Osmium Tetroxide (therapeutic use)
• Radioisotopes (therapeutic use)
• Synovitis (drug therapy, etiology, pathology)