Abstract | UNLABELLED:
Tyrosine supplementation has not consistently been found to improve neuropsychologic function in phenylketonuria (PKU), possibly because of failure to achieve adequate levels of tyrosine in the brain. OBJECTIVES: STUDY DESIGN: RESULTS: Plasma tyrosine levels were low normal at baseline. With supplementation there was a substantial but unsustained rise in plasma tyrosine. Calculated brain influx of tyrosine was 27% +/- 19% of normal before supplementation, increasing to 90% +/- 58% of normal with supplementation. Nevertheless, calculated influx remained less than 70% of normal at 50% of the time points. The calculated brain influxes of all other large neutral amino acids except tryptophan were 20% to 40% of normal before and with tyrosine supplementation. CONCLUSIONS:
Tyrosine supplementation in the diet for PKU produces marked but nonsustained increases in plasma tyrosine levels, with calculated brain influx that often remains suboptimal. This could explain the lack of consistent neuropsychologic benefit with tyrosine supplementation.
|
Authors | L R Kalsner, F J Rohr, K A Strauss, M S Korson, H L Levy |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 139
Issue 3
Pg. 421-7
(Sep 2001)
ISSN: 0022-3476 [Print] United States |
PMID | 11562623
(Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Adult
- Amino Acids
(metabolism)
- Brain
(metabolism)
- Child
- Female
- Humans
- Male
- Phenylketonurias
(drug therapy)
- Tyrosine
(blood, therapeutic use)
|