It was investigated whether the botanical
drug combination Sinupret is able to modulate the resistance of mice to a
respiratory tract infection with Sendai virus (
Parainfluenza viridae) if given prophylactically to the animals. Three doses of
Sinupret drops (SD) and
Sinupret tablets (ST, p.o.), and two active controls, the chemical secretolytic
ambroxol (p.o.) and the
immunomodulator Muramyldipeptide (MDP, i.v.) were used. Test and reference substances were applied at days - 3 and -1 before
infection, except MDP, which was given once on day--before
infection. CD4+ and CD8 + lymphocyte subpopulations were measured after
infection as indicators of immunological treatment response. Groups of 20 mice each were infected by intranasal application of Sendai virus under anaesthesia. We found that the 1 x and 5 x human doses of
Sinupret drops significantly prolonged the survival times (p < 0.05) compared to placebo. Additionally,
ambroxol and MDP were comparably less effective. In all groups, changes in CD4 + and CD8 + T-lymphocyte subpopulations of the peripheral blood were observed, but no clear relationship to the treatment results was seen. It was concluded that
Sinupret increases the resistance to an experimentally induced
respiratory tract infection in mice. Moreover, the effect of
Sinupret was superior to that of an
immunostimulant (MDP) and of a synthetic
secretagogue (ambroxolhydrochloride).