[Phenotype characteristics of skin dendritic cells in patients with psoriatic arthritis during the treatment with deresinated naphthalan].

Abstract

The study of the phenotype of immunocompetent dendritic cells of the skin in patients with psoriatic arthritis in the course of treatment with deresinated naphthalan (DRN) has revealed some aspects of the mechanism of therapeutic action of DRN. Use of the complex of monoclonal antibodies allowed the authors to determine membrane markers of various cells belonging to the system of mononuclear phagocytes and participating in development of immunoinflammation in the skin. The active stage of the disease is characterized by a fall in the number of CDIa+ cells. HLA-DR+ cells are more resistant. DRN therapy led to prevalence of CDIa+ cells.

• Authors: N G Badalov, N N Tupitsyn, V D Grigor'eva
• Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury (Vopr Kurortol Fizioter Lech Fiz Kult) 2001 Jul-Aug Issue 4 Pg. 29-32 ISSN: 0042-8787 [Print] Russia (Federation)
• Vernacular Title: Fenotipicheskie osobennosti dendriticheskikh kletok kozhi u bol'nykh psoriaticheskim artritom pod vliianiem lecheniia obessmolennym naftalainom.
• PMID: 11561301 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antigens, Surface
• HLA-DR Antigens
• Naphthalenes
• naphthalan

Topics

• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antigens, Surface (immunology)
• Arthritis, Psoriatic (immunology, pathology, therapy)
• Dendritic Cells (drug effects, immunology, pathology)
• Female
• HLA-DR Antigens (immunology)
• Humans
• Immunophenotyping
• Male
• Naphthalenes (therapeutic use)
• Skin (immunology, pathology)