[Antiarrhythmic properties of a cannabinoid (CB) receptor agonist].

Abstract

The cannabinoid (CB1) receptor agonist HU-210 (0.5 mg/kg, i.v.) exhibited a pronounced antiarrhythmic effect in rats with the adrenaline (epinephrine) and aconitine induced arrhythmia models. At the same time, the intracerebrovascular introduction of HU-210 (500 or 5000 ng) did not affect the adrenaline-induced arrhythmia. The CB1 receptor pretreatment (blocking) with the SR 141716 antagonist (3 mg/kg) and the introduction of a ganglion blocker (hexamethonium, 10 mg/kg) did not inhibit the antiarrhythmic effect of HU-210. It is concluded that the antiarrhythmic effect of intravenously injected HU-210 is neither related to the CB 1 receptor activation nor mediated by the autonomous (vegetative) nervous system.

• Authors: L N Maslov, Iu B Lishmanov, L A Maĭsmekulova, P Mechoulam
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2001 May-Jun Vol. 64 Issue 3 Pg. 37-40 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Antiarritmicheskie svoĭstva agonista kannabinoidnykh (CB) retseptorov.
• PMID: 11558437 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Receptors, Cannabinoid
• Receptors, Drug
• Dronabinol
• HU 211
• Aconitine
• Epinephrine

Topics

• Aconitine
• Animals
• Anti-Arrhythmia Agents (administration & dosage, pharmacology)
• Arrhythmias, Cardiac (chemically induced, drug therapy, physiopathology)
• Autonomic Nervous System
• Dronabinol (administration & dosage, analogs & derivatives, pharmacology)
• Epinephrine
• Injections, Intravenous
• Injections, Intraventricular
• Male
• Rats
• Rats, Wistar
• Receptors, Cannabinoid
• Receptors, Drug (agonists)