Abstract | OBJECTIVE: METHODOLOGY: We used reverse transcription polymerase chain reaction analysis of brush biopsy samples to detect mRNAs of interest. We then developed a semi-quantitative approach to compare subject groups. RESULTS: CONCLUSION: These findings imply that up-regulation of tachykinin production by cells present in the airway epithelium contributes to the pathophysiology of chronic bronchitis.
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Authors | P N Reynolds, R Scicchitano, M D Holmes |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 6
Issue 3
Pg. 187-97
(Sep 2001)
ISSN: 1323-7799 [Print] Australia |
PMID | 11555376
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Actins
- Interleukin-8
- Protein Precursors
- RNA, Messenger
- Tachykinins
- preprotachykinin
- protachykinin
- Intercellular Adhesion Molecule-1
- Neprilysin
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Topics |
- Actins
(metabolism)
- Adult
- Aged
- Bronchi
(metabolism)
- Bronchitis
(etiology, physiopathology)
- Bronchoscopy
- Chronic Disease
- Epithelium
(metabolism)
- Female
- Gene Expression
- Humans
- Intercellular Adhesion Molecule-1
(metabolism)
- Interleukin-8
(metabolism)
- Male
- Middle Aged
- Neprilysin
(metabolism)
- Protein Precursors
(metabolism)
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Smoking
(adverse effects, physiopathology)
- Tachykinins
(metabolism)
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