[Involvement of peripheral 5-HT2A receptor activation in inflammatory pain].

Abstract

Serotoninergic neuron is concerned as an one of the pivotal factor of the tissue inflammation which lead to pain behavior. Sarpogrelate HCl is a novel compound which may modulate inflammatory reaction through 5-HT2A receptor antagonist. We show the involvement of the 5-HT2A receptor activity in the inflammatory and neuropathic pain. Systemic or local sarpogrelate administration provokes antinociceptive effect on 5-HT- or formalin-produced inflammatory pain behaviour in relation to spinal glutamate. Local sarpogrelate inhibits apoptosis and neuronal degeneration after chronic construction injury(CCI). These effects are reversed by 5-HT2A receptor agonist. These results suggests sarpogrelate has a beneficial effect on hyperalgesia and neuropathic pain via inhibiting 5-HT2A receptor.

• Authors: O Nakanishi, T Ishikawa
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 59 Issue 9 Pg. 1675-80 (Sep 2001) ISSN: 0047-1852 [Print] Japan
• PMID: 11554035 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Receptor, Serotonin, 5-HT2A
• Receptors, Serotonin
• Serotonin Antagonists
• Succinates
• sarpogrelate

Topics

• Animals
• Humans
• Neuralgia (drug therapy, etiology)
• Neurogenic Inflammation (drug therapy, etiology)
• Receptor, Serotonin, 5-HT2A
• Receptors, Serotonin (metabolism)
• Serotonin Antagonists (pharmacology, therapeutic use)
• Succinates (pharmacology, therapeutic use)