Antioxidative and antitumor promoting effects of [6]-paradol and its homologs.

Abstract

Recently, considerable attention is focused on anti-carcinogenic phytochemicals, particularly those derived from medicinal or edible plants. [6]-Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. The compound has been reported to attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells. In this study, we performed several biochemical studies to evaluate and compare the cancer chemopreventive potential of [6]-paradol and its synthetic derivatives. [6]-Paradol and its synthetic nonpungent analog, [6]-dehydroparadol significantly decreased the incidence and the multiplicity of skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). Topical application of [6]-paradol and its derivatives inhibited TPA-induced ear edema and H(2)O(2) production and myeloperoxidase activity in the dorsal skin of mice. Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. These results indicate that [6]-paradol and its derivatives possess the cancer chemopreventive potential.

• Authors: W Y Chung, Y J Jung, Y J Surh, S S Lee, K K Park
• Journal: Mutation research (Mutat Res) Vol. 496 Issue 1-2 Pg. 199-206 (Sep 20 2001) ISSN: 0027-5107 [Print] Netherlands
• PMID: 11551496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents
• Antioxidants
• Carcinogens
• Ketones
• 9,10-Dimethyl-1,2-benzanthracene
• Guaiacol
• Hydrogen Peroxide
• 6-paradol
• Peroxidase
• Ornithine Decarboxylase
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Administration, Topical
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Antineoplastic Agents (pharmacology, therapeutic use)
• Antioxidants (pharmacology, therapeutic use)
• Carcinogens (pharmacology)
• DNA Damage (drug effects)
• Ear, External (drug effects, pathology)
• Edema (chemically induced, pathology, prevention & control)
• Epidermis (drug effects, enzymology)
• Female
• Guaiacol (administration & dosage, analogs & derivatives, therapeutic use)
• Hydrogen Peroxide (metabolism)
• Ketones (administration & dosage, therapeutic use)
• Mice
• Mice, Inbred ICR
• Ornithine Decarboxylase (biosynthesis)
• Peroxidase (biosynthesis)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (pharmacology)