[The liver monooxygenase system activity in the long-term compression syndrome and treatment with benzonal in prepubertal rats and rabbits].

Abstract

A compression syndrome was reproduced in rats and rabbits aged one month. Efficacy of the benzonal treatment in the postcompression period was evaluated by measuring the parameters of antipyrin pharmacokinetics, hexenal sleep duration, and the level of medium-molecular-weight (MMW) peptides in the blood serum. It was established that benzonal restored the detoxicating liver function (significantly reduced in animals with the compression syndrome) and eliminated the pronounced endotoxemia manifestations.

• Authors: F Kh Rakhmatullaev, Z Z Khakimov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2001 Mar-Apr Vol. 64 Issue 2 Pg. 69-71 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' monooksigenaznoĭ sistemy pecheni nepolovozrelykh krys i krolikov pri sindrome dlitel'nogo zdavlivaniia i korrektsii ego narusheniĭ benzonalom.
• PMID: 11548454 (Publication Type: English Abstract, Journal Article)

Chemical References

• Barbiturates
• Cytochrome P-450 Enzyme System
• benzobarbital

Topics

• Age Factors
• Animals
• Barbiturates (therapeutic use)
• Crush Syndrome (drug therapy, enzymology)
• Cytochrome P-450 Enzyme System (biosynthesis)
• Enzyme Induction
• Female
• Liver (enzymology)
• Male
• Rabbits
• Rats