Abstract | PURPOSE: MATERIALS AND METHODS: We treated 90 patients with stress urinary incontinence and urethral hypermobility with 1 to 3 injections of Contigen implant (C. R. Bard, Inc., Covington, Georgia) between June 1996 and October 1998. Observations at 3, 6 and 12 months included continence grade, 7-day voiding diaries and quality of life questionnaires. Abdominal leak point pressure was determined at baseline and 12 months. RESULTS: At the 6-month followup 68 patients remained in the study, of whom 30 (44%) were dry and 24 (35%) were improved. Of the 58 patients who reached the 12-month followup 19 (33%) were dry and 19 (33%) were improved. Considering all patients entered into the study at 6 months 30 (33%) were dry and 24 (27%) were improved. Of the original 90 patients 19 (21%) were dry and 19 (21%) were improved at 12 months. The probability of maintaining initial improvement for 12 months was 44%. The success of bulking agent therapy was not predicted by the initial incontinence grade. Improved continence grade correlated with improved leak point pressure. CONCLUSIONS: This therapy is appropriate in women with urethral hypermobility who wish to avoid surgical risks and in those in whom surgery is ill advised.
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Authors | A E Bent, J Foote, S Siegel, G Faerber, R Chao, E A Gormley |
Journal | The Journal of urology
(J Urol)
Vol. 166
Issue 4
Pg. 1354-7
(Oct 2001)
ISSN: 0022-5347 [Print] United States |
PMID | 11547073
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- glutaraldehyde-cross-linked collagen
- Collagen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Collagen
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Prospective Studies
- Prostheses and Implants
- Urethral Diseases
(complications)
- Urinary Incontinence, Stress
(etiology, therapy)
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