Abstract | PURPOSE: METHODS: During isoflurane anesthesia, MCAo was achieved via a temporal craniotomy. Thirty minutes before MCAo the rats were randomized to receive one of the following which was maintained throughout the study. Halothane (n=20)-1.2 MAC halothane, thiopentone (n=20), methohexital (n=20), or pentobarbitone (n=20). The first ten animals in each barbiturate group received the respective barbiturate in a dose sufficient to maintain burst-suppression of the electroencephalogram (3-5 bursts x min(-1)). The subsequent ten animals in each barbiturate group received 40% of the burst-suppression dose. After 180 min of MCAo and 120 min of reperfusion, cerebral injury was assessed. RESULTS: CONCLUSIONS: These data are inconsistent with the longstanding assumption that electrophysiologically comparable doses of the various classes of barbiturates have equivalent protective efficacy. They in turn suggest that mechanisms other than, or at least in addition to, metabolic suppression may contribute to the protective effect of barbiturates.
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Authors | D J Cole, L M Cross, J C Drummond, P M Patel, W K Jacobsen |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 48
Issue 8
Pg. 807-14
(Sep 2001)
ISSN: 0832-610X [Print] United States |
PMID | 11546724
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Free Radicals
- Nitric Oxide
- Glutamic Acid
- Methohexital
- Pentobarbital
- Thiopental
- Calcium
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Topics |
- Animals
- Brain
(drug effects, metabolism)
- Brain Ischemia
(drug therapy, physiopathology)
- Calcium
(metabolism)
- Electroencephalography
(drug effects)
- Free Radicals
- Glutamic Acid
(toxicity)
- Male
- Methohexital
(therapeutic use)
- Nitric Oxide
(toxicity)
- Pentobarbital
(therapeutic use)
- Rats
- Rats, Inbred SHR
- Thiopental
(therapeutic use)
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