[Hypolipidemic and antioxidant effects of pyridyl-3-glyoxylic acid].

Abstract

Pyridyl-3-glyoxylic acid reduced the blood cholesterol and triglycerides, normalized the lipoprotein spectrum, markedly decreased the intensity of lipid peroxidation, and increased the superoxide dismutase enzyme activity in the experimental rabbits with cholesterol atherosclerosis model. The efficacy of the compound exceeded that of nicotinic acid used as the reference compound.

• Authors: Kh U Sadykova, A Kh Abdullaev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2001 Jan-Feb Vol. 64 Issue 1 Pg. 57-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: O gipolipidemicheskom i antioksidantnom éffekte piridil-3-glioksilovoĭ kisloty.
• PMID: 11544807 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Glyoxylates
• Hypolipidemic Agents
• Lipoproteins
• Pyridines
• Triglycerides
• pyridine-3-glyoxylic acid
• Malondialdehyde
• Cholesterol
• Superoxide Dismutase

Topics

• Animals
• Antioxidants (pharmacology, toxicity)
• Arteriosclerosis (chemically induced, drug therapy)
• Cholesterol (analysis)
• Glyoxylates (metabolism, pharmacology, toxicity)
• Hypolipidemic Agents (metabolism, pharmacology, toxicity)
• Lipid Peroxidation (drug effects)
• Lipoproteins (analysis, chemistry)
• Malondialdehyde (analysis)
• Pyridines (metabolism, pharmacology, toxicity)
• Rabbits
• Superoxide Dismutase (analysis)
• Toxicity Tests, Acute
• Triglycerides (analysis)