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Isochromosome 17 in a case of eosinophilic leukaemia. An abnormality common to eosinophilic and neutrophilic cells.

Abstract
In a patient with eosinophilic leukaemia, serial chromosome studies using the Giemsa banding technique revealed a similar marker chromosome, identified as an isochromosome 17, in all bone marrow metaphases analysed. There was no Ph-1-chromosome. The cytogenetic data support the view that eosinophilic leukaemia is a specific disease entity, and suggest that both eosinophilic and neutrophilic cells are involved in the leukaemic process.
AuthorsF Mitelman, A Panani, L Brandt
JournalScandinavian journal of haematology (Scand J Haematol) Vol. 14 Issue 4 Pg. 308-12 (May 1975) ISSN: 0036-553X [Print] Denmark
PMID1153958 (Publication Type: Journal Article)
Topics
  • Bone Marrow Cells
  • Cell Division
  • Chromosome Aberrations
  • Chromosomes, Human, 16-18
  • Eosinophils
  • Humans
  • Karyotyping
  • Leukemia (genetics)
  • Male
  • Middle Aged
  • Mitosis
  • Neutrophils

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