[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema].

Abstract

Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated the efficacy and safety of a climbazole 0.65% shampoo on seborrheic dermatitis of 30 volunteers. Subjects were diagnosed as having moderate to severe seborrheic dermatitis of the scalp. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff.

• Authors: W Wigger-Alberti, K Kluge, P Elsner
• Journal: Praxis (Praxis (Bern 1994)) Vol. 90 Issue 33 Pg. 1346-9 (Aug 16 2001) ISSN: 1661-8157 [Print] Switzerland
• Vernacular Title: Klinische Wirksamkeit und Verträglichkeit eines Climbazol-haltigen Antischuppen-Shampoos bei Patienten mit seborrhoischem Kopfhautekzem.
• PMID: 11534318 (Publication Type: Journal Article)

Chemical References

• Hair Preparations
• Imidazoles
• climbazole

Topics

• Adult
• Dermatitis, Seborrheic (drug therapy)
• Dermatomycoses (drug therapy)
• Dose-Response Relationship, Drug
• Female
• Hair Preparations
• Humans
• Imidazoles (administration & dosage)
• Malassezia (drug effects)
• Male
• Middle Aged
• Treatment Outcome