Abstract | BACKGROUND:
Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. METHODS: Computer stored data on digitoxin concentrations in plasma from 9271 patients with cardiac disease were used to define a user population. Age and sex matched controls from the Norwegian Cancer Registry were used to calculate the number of expected cancer cases. RESULTS: CONCLUSION:
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Authors | J Haux, O Klepp, O Spigset, S Tretli |
Journal | BMC cancer
(BMC Cancer)
Vol. 1
Pg. 11
( 2001)
ISSN: 1471-2407 [Electronic] England |
PMID | 11532201
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Arrhythmia Agents
- Digitoxin
|
Topics |
- Age Factors
- Aged
- Anti-Arrhythmia Agents
(administration & dosage, adverse effects, blood, therapeutic use)
- Case-Control Studies
- Cohort Studies
- Digitoxin
(administration & dosage, adverse effects, blood, therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Heart Diseases
(complications, drug therapy)
- Humans
- Incidence
- Male
- Neoplasms
(blood, chemically induced, epidemiology)
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