Lipopolysaccharides in the development of the Guillain-Barré syndrome and Miller Fisher syndrome forms of acute inflammatory peripheral neuropathies.

Abstract

Guillain-Barré syndrome (GBS), an acute inflammatory polyneuropathy, is preceded in most cases by an infectious illness, and Campylobacter jejuni, a leading cause of acute gastroenteritis, is the most common antecedent to GBS and its ocular variant, Miller Fisher syndrome (MFS). O (Penner) serotyping is considered to distinguish between C. jejuni strains based on differences in lipopolysaccharide (LPS) structure. Serotypes of C. jejuni uncommon in enteritis, such as serotype O:19 and O:41, have been associated with GBS. Chemical studies on the core oligosaccharide (OS) of C. jejuni LPSs from serotypes including O:1, O:2, O:4, O:10, O:19, O:23, O:36 and O:41 have revealed structures that mimic human gangliosides including GM1, GD1a, GD2, GD3, and GM2. Research has focused on the view that molecular mimicry may be a factor in the pathogenesis of GBS. Serum antibodies against gangliosides, particularly GM1 ganglioside, are present in 30% of GBS patients, and are highly associated with MFS, but are generally absent in enteritis cases uncomplicated by neuropathy. Collective data from human and animal studies with anti-ganglioside antibodies suggest a pathogenic role for the antibodies. Many aspects of the pathogenesis of GBS are unclear, in particular how LPS is presented to T cells or the role of host factors in disease development.

• Authors: M M Prendergast, A P Moran
• Journal: Journal of endotoxin research (J Endotoxin Res) Vol. 6 Issue 5 Pg. 341-59 ( 2000) ISSN: 0968-0519 [Print] United States
• PMID: 11521055 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies, Bacterial
• Gangliosides
• Lipopolysaccharides

Topics

• Animals
• Antibodies, Bacterial (blood, immunology)
• Campylobacter Infections (complications, immunology, microbiology)
• Campylobacter jejuni (classification, immunology, pathogenicity)
• Carbohydrate Sequence
• Cross Reactions
• Gangliosides (chemistry, immunology)
• Guillain-Barre Syndrome (etiology, immunology, microbiology)
• Humans
• Lipopolysaccharides (chemistry, immunology, toxicity)
• Miller Fisher Syndrome (etiology, immunology, microbiology)
• Models, Biological
• Molecular Mimicry
• Molecular Sequence Data
• Serotyping
• T-Lymphocytes (immunology)