Cytotoxic diacetylenes from the stony coral Montipora species.

Abstract

Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce apoptosis in human colon tumor cell.

• Authors: N Alam, B H Bae, J Hong, C O Lee, K S Im, J H Jung
• Journal: Journal of natural products (J Nat Prod) Vol. 64 Issue 8 Pg. 1059-63 (Aug 2001) ISSN: 0163-3864 [Print] United States
• PMID: 11520227 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkynes
• Antineoplastic Agents
• montiporyne A
• Acetylene

Topics

• Acetylene (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Alkynes
• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Chromatography, High Pressure Liquid
• Cnidaria (chemistry)
• Colonic Neoplasms
• Humans
• Korea
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Stereoisomerism
• Tumor Cells, Cultured (drug effects, metabolism)
• X-Ray Diffraction