A long-term review of the treatment of patients with Ewing's sarcoma in one institution.

Abstract

AIMS:

The treatment of patients suffering from Ewing's sarcoma has changed over the last three decades. We report the analyses, significant prognostic factors, interdisciplinary approach and development of therapy in one institution in Austria.

METHODS:

One hundred and forty-two patients treated for Ewing's sarcoma between 1949 and 1994 were reviewed. Median follow-up was 8.5 years. Fifty-six patients were treated between 1949 and 1980 (group 1), and 86 patients between 1981 and 1994 (group 2). Patients in group 1 were treated with polychemotherapy. Patients in group 2 were treated with a neoadjuvant CESS (Cooperative Ewing's Sarcoma Study) regimen. In group 1, 24 patients underwent biopsy only, 32 patients had a definitive operation, 48 patients received either radiation therapy only or additional radiation therapy compared with in group 2: 6, 80 and 44 cases, respectively.

RESULTS:

Five-year overall survival (OS) increased from 27% to 57%. Significant prognostic factors for OS were pre-operative metastases (P=0.0001), tumour location (P=0.0048), type of chemotherapy (P=0.002) and response to chemotherapy (P=0.0004). Chemotherapy (P=0.037), tumour location (P=0.0017) and metastases at diagnosis (P=0.0025) were significant.

CONCLUSION:

The most effective treatment of Ewing's sarcoma is chemotherapy.

• Authors: M Sluga, R Windhager, S Lang, H Heinzl, P Krepler, F Mittermayer, M Dominkus, A Zoubek, R Kotz
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 27 Issue 6 Pg. 569-73 (Sep 2001) ISSN: 0748-7983 [Print] England
• PMID: 11520091 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2001 Harcourt Publishers Limited.

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Austria
• Biopsy, Needle
• Bone Neoplasms (diagnosis, mortality, therapy)
• Child
• Child, Preschool
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• Multivariate Analysis
• Orthopedic Procedures (methods)
• Probability
• Radiotherapy, Adjuvant (methods)
• Retrospective Studies
• Sarcoma, Ewing (diagnosis, mortality, therapy)
• Sensitivity and Specificity
• Survival Analysis
• Time Factors
• Treatment Outcome