Abstract | OBJECTIVES: METHODS: Ten normal subjects and 10 patients with gastroesophageal reflux disease were evaluated. PH-metry was performed using two glass pH flexible probes with distal incorporated electrodes. The two catheters were introduced nasally under fluoroscopy. One probe was positioned in the gastric body; the other was placed 5 cm above the lower esophageal sphincter which had been evaluated manometrically before the study. Recording lasted without interruption for 48 h. Patients and normal subjects were assigned to receive hyoscine N-butylbromide (10 mg p.o. t.i.d.) for 24 h followed by a placebo for another 24 h or vice versa in a random manner. The pH was analyzed for a total number of acid refluxes and percentage of the period with pH <4 in the esophagus and the mean gastric pH in 24 h, before and after treatment with hyoscine N-butylbromide. RESULTS: CONCLUSIONS:
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Authors | A F Ciccaglione, L Grossi, G Cappello, M G Malatesta, A Ferri, S Toracchio, L Marzio |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 96
Issue 8
Pg. 2306-11
(Aug 2001)
ISSN: 0002-9270 [Print] United States |
PMID | 11519531
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Muscarinic Antagonists
- Butylscopolammonium Bromide
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Topics |
- Adult
- Butylscopolammonium Bromide
(adverse effects, pharmacology)
- Case-Control Studies
- Female
- Gastroesophageal Reflux
(drug therapy)
- Humans
- Hydrogen-Ion Concentration
- Male
- Muscarinic Antagonists
(adverse effects, pharmacology)
- Statistics, Nonparametric
- Treatment Outcome
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