Prophylactic ondansetron does not improve patient satisfaction in women using PCA after Caesarean section.

Abstract

Eighty-one consenting women undergoing elective Caesarean section under spinal anaesthesia were randomly divided into two groups. In Group O patients, ondansetron 4 mg was given intravenously at the end of the surgery and 8 mg added to the morphine solution in the PCA syringe. Patients in Group P received only morphine via PCA syringe. Analgesia and nausea were measured until PCA was discontinued 24 h after the operation. Women in the two groups were similar with respect to age, duration of use of the PCA, amount of morphine used, previous history of PONV, and incidence of motion sickness and morning sickness during the current pregnancy. The number of women who complained of nausea and those needing rescue antiemetic medication was significantly less in Group O. However, there was no statistically significant difference between the two groups in the patient's perception of the control of nausea and their overall satisfaction. It was noted that PONV was more frequent among women who had significant morning sickness during early pregnancy and ondansetron was beneficial in reducing PONV in these women. Although the ondansetron reduced the incidence of PONV and the need for further antiemetic medication, this did not affect patient's satisfaction regarding their postoperative care.

• Authors: V T Cherian, I Smith
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 87 Issue 3 Pg. 502-4 (Sep 2001) ISSN: 0007-0912 [Print] England
• PMID: 11517140 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Opioid
• Antiemetics
• Serotonin Antagonists
• Ondansetron
• Morphine

Topics

• Analgesia, Patient-Controlled (adverse effects)
• Analgesics, Opioid (adverse effects)
• Anesthesia, Obstetrical (methods)
• Anesthesia, Spinal
• Antiemetics (therapeutic use)
• Cesarean Section
• Double-Blind Method
• Female
• Humans
• Morphine (adverse effects)
• Ondansetron (therapeutic use)
• Patient Satisfaction
• Postoperative Nausea and Vomiting (chemically induced, prevention & control)
• Pregnancy
• Serotonin Antagonists (therapeutic use)