Abstract | PURPOSE: To assess the efficacy of Biafine cream in preventing Grade 2 acute radiation dermatitis, according to the National Cancer Institute of Canada skin radiation toxicity criteria in patients undergoing concomitant adjuvant chemotherapy and radiotherapy to the breast. METHODS AND MATERIALS: Sixty patients participated in this study. Patients were treated with a lumpectomy followed by concomitant chemotherapy and radiotherapy to the breast. Biafine cream was applied daily, starting on the first day and ending 2 weeks post- radiotherapy. Patients underwent weekly skin assessments throughout radiotherapy and at 2 and 4 weeks after treatment. Outcome measures were assessed using a Skin Assessment Questionnaire that was scored according to the National Cancer Institute of Canada skin radiation toxicity criteria and a self-administered questionnaire that evaluated skin symptoms. RESULTS: The maximum skin toxicity observed during the course of treatment was as follows: less than Grade 2 toxicity, 15% (9 patients); Grade 2, 83% (50 patients); Grade 3, 2% (1 patient); Grade 4, 0% (0 patients). The majority of the radiation dermatitis was observed after 3 weeks of radiotherapy. CONCLUSION:
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Authors | E Szumacher, A Wighton, E Franssen, E Chow, M Tsao, I Ackerman, L Andersson, J Kim, A Wojcicka, Y Ung, K Sixel, C Hayter |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 51
Issue 1
Pg. 81-6
(Sep 01 2001)
ISSN: 0360-3016 [Print] United States |
PMID | 11516855
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Biafine
- Dermatologic Agents
- Emulsions
- Lipids
- Silver Sulfadiazine
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, radiotherapy, surgery)
- Chemotherapy, Adjuvant
- Dermatologic Agents
(therapeutic use)
- Emulsions
- Female
- Humans
- Lipids
- Mastectomy, Segmental
- Middle Aged
- Outcome Assessment, Health Care
- Radiodermatitis
(pathology, prevention & control)
- Silver Sulfadiazine
(adverse effects, therapeutic use)
- Surveys and Questionnaires
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