Widespread hematogenous metastases and Trousseau's syndrome in gastric adenocarcinoma.

Abstract

A case of widespread hematogenous metastases and Trousseau's syndrome is reported in a 40 year-old white housewife with gastric cancer, presenting subdural hematoma, ecchymoses, epistaxis, stomach and uterine bleeding. After undergoing hematoma drainage, she was unsuccessfully treated with platelets, red blood cells, plasma cryoprecipitate transfusions, and antibiotics. Necropsy disclosed gastric ring-signet adenocarcinoma invading the serous layer, with massive disseminated intravascular coagulation and systemic neoplastic embolism. Multiple old and recent hyaline (rich in fibrin and platelets) microthrombi, and tumor emboli were observed in the bone marrow, meninges, liver, lungs, kidneys, lymph nodes, adrenals, thyroid, heart, pancreas, and ovaries (Krukenberg tumor).

• Authors: V M dos Santos, D B Rodrigues, E C Castro, J C Saldanha, S Soares, V P Teixeira, M A dos Reis
• Journal: Revista do Hospital das Clinicas (Rev Hosp Clin Fac Med Sao Paulo) 2001 May-Jun Vol. 56 Issue 3 Pg. 91-6 ISSN: 0041-8781 [Print] Brazil
• PMID: 11514909 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Blood Coagulation Disorders (complications, pathology)
• Carcinoma, Signet Ring Cell (blood, complications, secondary)
• Fatal Outcome
• Female
• Humans
• Stomach Neoplasms (blood, complications, pathology)
• Syndrome