Highly increased CSF tau protein and decreased beta-amyloid (1-42) in sporadic CJD: a discrimination from Alzheimer's disease?

Abstract

The aim was to quantify tau protein and beta-amyloid (Abeta42) in the CSF of patients with sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), and controls. Double sandwich enzyme linked immunosorbent assays (ELISAs) were used for measurements. Tau was increased 58-fold in CJD and 3.5-fold in AD compared with controls, whereas Abeta42 was decreased 0.5-fold in both CJD and AD. A cut off level for tau protein at 2131 pg/ml successfully discriminated CJD from AD (100% specificity and 93% sensitivity). Tau protein concentration in CSF is probably an additional useful marker in differentiating CJD from AD.

• Authors: E Kapaki, K Kilidireas, G P Paraskevas, M Michalopoulou, E Patsouris
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 71 Issue 3 Pg. 401-3 (Sep 2001) ISSN: 0022-3050 [Print] England
• PMID: 11511720 (Publication Type: Journal Article, Validation Study)

Chemical References

• Amyloid beta-Peptides
• Biomarkers
• tau Proteins

Topics

• Aged
• Alzheimer Disease (cerebrospinal fluid, diagnosis)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Analysis of Variance
• Biomarkers (cerebrospinal fluid)
• Case-Control Studies
• Creutzfeldt-Jakob Syndrome (cerebrospinal fluid, diagnosis)
• Diagnosis, Differential
• Discriminant Analysis
• Enzyme-Linked Immunosorbent Assay (methods, standards)
• Female
• Humans
• Male
• Middle Aged
• Sensitivity and Specificity
• Time Factors
• tau Proteins (cerebrospinal fluid)