Abstract | OBJECTIVE AND METHODS: The imbalance between matrix metalloproteinases ( MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) is considered to be an important determination of deposition and breakdown of the extracellular matrix. To investigate the antifibrogenetic effect of interferon-alpha (IFN-alpha) treatment on factors regulating hepatic fibrosis, serum MMP-1, MMP-2, TIMP-1 and TIMP-2 levels were measured by the one-step sandwich enzyme immunoassay in 27 patients with chronic hepatitis C and compared with the histological status of the patients before and at the end of treatment. RESULTS: After 6 months of IFN-alpha treatment, the histological status of liver fibrosis showed improvement in 9 patients (IF group) and no change or a worsening in 18 patients (NIF group). Compared with pretreatment levels, in the IF group, IFN treatment caused a significant increase in the MMP-1/TIMP-1 ratio. In the NIF group, however, the MMP-1/TIMP-1 ratio tended towards a decrease; moreover, there was not only a significant increase in TIMP-2 levels but also a tendency towards an increase in TIMP-1 levels. CONCLUSION:
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Authors | T Ninomiya, S Yoon, H Nagano, Y Kumon, Y Seo, M Kasuga, Y Yano, M Nakaji, Y Hayashi |
Journal | Intervirology
(Intervirology)
Vol. 44
Issue 4
Pg. 227-31
( 2001)
ISSN: 0300-5526 [Print] Switzerland |
PMID | 11509885
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifibrinolytic Agents
- Biomarkers
- Interferon-alpha
- Matrix Metalloproteinase Inhibitors
- Protease Inhibitors
- Tissue Inhibitor of Metalloproteinase-1
- Tissue Inhibitor of Metalloproteinase-2
- Matrix Metalloproteinases
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 1
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Topics |
- Antifibrinolytic Agents
(therapeutic use)
- Biomarkers
(blood)
- Female
- Hepatitis C, Chronic
(blood, drug therapy)
- Humans
- Injections, Intramuscular
- Interferon-alpha
(therapeutic use)
- Male
- Matrix Metalloproteinase 1
(blood)
- Matrix Metalloproteinase 2
(blood)
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(blood)
- Middle Aged
- Protease Inhibitors
(blood)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Tissue Inhibitor of Metalloproteinase-2
(blood)
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