Insulin responses to crude cholecystokinin-pancreozymin in normal subjects, in patients with chronic pancreatitis and patients with mild maturity onset diabetes.

Abstract

The effects of repeated injections of 75 U crude cholecystolinin-pancreozymin (CCK-PZ) at increasing plateau glucose concentrations achieved by glucose infusion were studied in 15 controls, 8 chronic pancreatitics and 8 mild maturity onset diabetics. In control subjects CCK-PZ alone caused minor insulin release but proportinally greater secretion with increasing blood glucose concentrations. Chronic pancreatitis patients who had normal responses to intravenous glucose responded normally to the CCK-PZ but at significantly higher plateau glucose levels. Diabetics had no response to IV glucose boluses of 5 g or 10 g, but with glucose infusions of 250-500 mg/min had almost normal insulin responses to CCK-PZ. The responses to CCK-PZ plus glucose were greater than either stimulus alone, indicating an interaction between these and the beta cell. These studies suggest that the gut homone-receptor in the beta cell is intact in maturity onset diabetes and chronic pancreatitis, whether the glucose receptor is normal or defective. The peptide-responsible in the crude CCK-PZ is not secretin, glucagon or gut glucagon, but may be gastric inhibitory polypeptide (GIP) since pure CCK-PZ has no insuli releasing properties.

• Authors: W J Kalk, A I Vinik, J L Botha, P Keller, W P Jackson
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 41 Issue 1 Pg. 172-6 (Jul 1975) ISSN: 0021-972X [Print] United States
• PMID: 1150859 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Insulin
• Cholecystokinin
• Glucose

Topics

• Adult
• Blood Glucose (metabolism)
• Cholecystokinin (pharmacology)
• Chronic Disease
• Diabetes Mellitus (blood)
• Glucose (pharmacology)
• Humans
• Insulin (blood)
• Male
• Middle Aged
• Pancreatitis (blood)
• Stimulation, Chemical