Abstract |
Although antioxidant status has been implicated in the pathogenesis of malaria, these factors need further characterization. A longitudinal study was conducted involving 273 children 1-10 years of age with acute, uncomplicated malaria in Kampala, Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at enrollment and on day 7. Malaria parasitemia was measured at enrollment, on day 3, and on day 7. Malaria parasitemia had completely cleared in 57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin A, alpha-carotene, beta-carotene, lycopene, lutein/ zeaxanthin, and vitamin E were depressed at enrollment and increased by day 7. Multivariate analyses showed that higher plasma lycopene concentrations at enrollment were associated with clearance of parasitemia between enrollment and day 3 (odds ratio = 1.46, 95% confidence interval = 1.07-2.06, per 0.10 micromol/L of lycopene). This study suggests that children with acute malaria have depressed plasma concentrations of antioxidants, and that higher plasma lycopene is associated with more rapid clearance of malaria parasitemia.
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Authors | A Metzger, G Mukasa, A H Shankar, G Ndeezi, G Melikian, R D Semba |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 65
Issue 2
Pg. 115-9
(Aug 2001)
ISSN: 0002-9637 [Print] United States |
PMID | 11508384
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antioxidants
- Xanthophylls
- Zeaxanthins
- beta Carotene
- Vitamin A
- Vitamin E
- Carotenoids
- alpha-carotene
- Lycopene
- Lutein
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Topics |
- Acute Disease
- Animals
- Antioxidants
(analysis)
- Carotenoids
(blood)
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Lutein
(blood)
- Lycopene
- Malaria, Falciparum
(blood, epidemiology, parasitology)
- Male
- Parasitemia
- Plasmodium falciparum
(isolation & purification)
- Uganda
(epidemiology)
- Vitamin A
(blood)
- Vitamin E
(blood)
- Xanthophylls
- Zeaxanthins
- beta Carotene
(analogs & derivatives, blood)
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