In vitro studies of the anticalculus efficacy of a sodium hexametaphosphate whitening dentifrice.

Laboratory studies involving crystal growth inhibition and plaque biofilm calcification were conducted to confirm the anticalculus potential of a dual-action whitening dentifrice containing sodium hexametaphosphate, a novel, enamel-safe, antitartar agent. Calcium hydroxyapatite crystal growth was significantly inhibited following direct supernate treatments by hexametaphosphate in solution and when formulated into the dual-action whitening dentifrice. Similarly, plaque biofilm calcification was significantly inhibited by supernate treatments of the hexametaphosphate whitening dentifrice. The activity of hexametaphosphate dentifrice in plaque biofilm calcification protocols exceeded that produced by commercial dentifrices containing polycarboxylic acid, metal ion and pyrophosphate tartar control ingredients. Results predict excellent clinical activity for hexametaphosphate dentifrice for the prevention of supragingival calculus formation. Published double-blind, randomized clinical studies confirm the validity of these laboratory models for the screening of potentially improved tartar control ingredients.
AuthorsDonald J White, Ed R Cox, Elaine M Suszcynskymeister, Arif A Baig
JournalThe Journal of clinical dentistry (J Clin Dent) Vol. 13 Issue 1 Pg. 33-7 ( 2002) ISSN: 0895-8831 [Print] United States
PMID11507930 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Complex Mixtures
  • Crest Dual Action Whitening dentifrice
  • Crest Tartar Control
  • Dentifrices
  • Diphosphates
  • Drug Combinations
  • Phosphates
  • Toothpastes
  • hydrated silica gel-based toothpaste
  • Silicic Acid
  • Triclosan
  • Sodium Fluoride
  • Durapatite
  • sodium polymetaphosphate
  • Fluorides
  • Complex Mixtures
  • Crystallization
  • Dental Calculus (prevention & control)
  • Dental Plaque (chemistry)
  • Dentifrices (therapeutic use)
  • Diphosphates (therapeutic use)
  • Drug Combinations
  • Durapatite (chemistry)
  • Fluorides
  • Hydrogen-Ion Concentration
  • Phosphates (therapeutic use)
  • Silicic Acid
  • Sodium Fluoride (therapeutic use)
  • Tooth Bleaching
  • Toothpastes
  • Triclosan

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: