Elevation of serum cystatin C concentrations in patients with chronic liver disease.

Abstract

OBJECTIVE:

We examined serum cystatin C concentrations in patients to explore the possible clinical application of cystatin C as a marker of disease severity in cases of chronic liver diseases.

METHODS:

Serum cystatin C concentrations were determined by an enzyme-linked immunosorbent assay kit in 103 patients with various chronic liver diseases and compared with concentrations in healthy control volunteers.

RESULTS:

The mean cystatin C concentration was 0.68 +/- 0.03 mg/l in chronic hepatitis patients, 1.13 +/- 0.09 mg/l in liver cirrhosis patients and 1.16 +/- 0.10 mg/l in hepatocellular carcinoma patients, all significantly higher than concentrations in the control volunteers (P < 0.0001). Significant correlations were observed between cystatin C concentrations and total bilirubin levels, albumin levels, platelet levels, type IV collagen levels and hyaluronic acid levels. Serum cystatin C concentrations correlated well with histological stages despite the lack of correlation with histological grades.

CONCLUSION:

Our results show that serum cystatin C increases with the progression of chronic liver disease and that it is a potential marker for liver fibrosis.

• Authors: M Takeuchi, Y Fukuda, I Nakano, Y Katano, T Hayakawa
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 13 Issue 8 Pg. 951-5 (Aug 2001) ISSN: 0954-691X [Print] England
• PMID: 11507361 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• CST3 protein, human
• Cystatin C
• Cystatins
• Serum Albumin
• Hyaluronic Acid
• Collagen
• Bilirubin

Topics

• Bilirubin (blood)
• Biomarkers (blood)
• Carcinoma, Hepatocellular (blood, diagnosis)
• Chronic Disease
• Collagen (blood)
• Cystatin C
• Cystatins (blood)
• Disease Progression
• Enzyme-Linked Immunosorbent Assay
• Female
• Hepatitis, Chronic (blood, diagnosis)
• Humans
• Hyaluronic Acid (blood)
• Liver (pathology)
• Liver Cirrhosis (blood, diagnosis)
• Liver Diseases (blood, diagnosis, pathology)
• Liver Neoplasms (blood, diagnosis)
• Male
• Middle Aged
• Platelet Count
• Serum Albumin (analysis)