Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis.

Abstract

Subacute granulomatous thyroiditis (SAT) is a self-limiting systemic inflammatory disorder with possible transient expression of thyroid antibodies. Persistent hypothyroidism is uncommon. The interleukin-1 receptor antagonist IL-1ra is an inhibitor of IL-1 activity and allele 2 of the IL-1ra gene is associated with inflammatory diseases and IL-1ra production. Forty-eight subjects with SAT were investigated. Polymorphisms of IL-1ra, IL-1beta-511 and TNFalpha genes were studied with respect to thyroid peroxidase antibodies (TPOab), thyroglobulin antibodies, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Serum IL-1ra levels were measured. An increased allelic frequency (43% vs 22%, p=0.039) and carriage rate (79% vs 41%, p=0.018) for IL-1ra allele 2 were observed with expression of TPOab in 14 (29.2%) subjects compared with those with negative findings. The carriage rate for both IL-1ra allele 2 and IL-1beta-511 allele 2 was also increased with TPOab expression (71% vs 27%, p=0.004, respectively). No difference in allele frequency or carriage rate was found compared with healthy controls. Serum IL-1ra levels correlated with S-CRP (r=0.41, p=0.004) and ESR (r=0.34, p=0.016), but the association with genes or thyroid antibodies was statistically insignificant. S-CRP levels and ESR were lower and negatively correlated with expression of TPOab (r=-0.27, p=0.046 and r=-0.32, p=0.017). This study describes the multiplicity of the mechanisms responsible for the severity of the acute-phase response during the course of SAT. IL-1ra may have a significant anti-inflammatory role in SAT. Presence of IL-1ra allele 2 increases the risk of developing TPOab.

• Authors: K Luotola, P Mantula, J Salmi, A M Haapala, P Laippala, M Hurme
• Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (APMIS) Vol. 109 Issue 6 Pg. 454-60 (Jun 2001) ISSN: 0903-4641 [Print] Denmark
• PMID: 11506478 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• DNA Primers
• IL1RN protein, human
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1
• Sialoglycoproteins
• Tumor Necrosis Factor-alpha
• C-Reactive Protein
• Thyroglobulin
• Iodide Peroxidase

Topics

• Adult
• Aged
• Alleles
• Autoantibodies (blood)
• Base Sequence
• Blood Sedimentation
• C-Reactive Protein (metabolism)
• Case-Control Studies
• DNA Primers (genetics)
• Female
• Humans
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1 (genetics)
• Iodide Peroxidase (immunology)
• Male
• Middle Aged
• Polymorphism, Genetic
• Risk Factors
• Sialoglycoproteins (genetics)
• Thyroglobulin (immunology)
• Thyroiditis, Subacute (enzymology, etiology, genetics, immunology)
• Tumor Necrosis Factor-alpha (genetics)