Abstract |
Common colds are one of the most frequent acute illnesses with major economical impact. Echinaceae purpureae herba ( Echinacin, EC31J0) has shown promising results in the relief of common cold symptoms and the time taken to improvement compared to placebo. This study was aimed to confirm these findings by performing a randomised, double-blind, placebo-controlled clinical trial. A total of 80 adult male or female patients with first signs of a cold were recruited. The number of days of illness with a complete picture of the common cold (defined by the modified Jackson score of at least 5 points and experience of rhinorrhea and/or a subjective sensation of having a cold) was the primary end-point. In the verum group the median time of illness was 6.0 days compared to 9.0 days in the placebo group, assigning zero time for patients without a complete picture (one-sided p = 0.0112). EC31J0 was well tolerated and clinically effective in alleviating symptoms more rapidly than placebo in patients with a common cold.
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Authors | B Schulten, M Bulitta, B Ballering-Brühl, U Köster, M Schäfer |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 51
Issue 7
Pg. 563-8
( 2001)
ISSN: 0004-4172 [Print] Germany |
PMID | 11505787
(Publication Type: Clinical Trial, Clinical Trial, Phase IV, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Area Under Curve
- Common Cold
(drug therapy)
- Double-Blind Method
- Echinacea
(chemistry, therapeutic use)
- Female
- Humans
- Male
- Phytotherapy
- Plants, Medicinal
- Sample Size
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