Abstract | OBJECTIVE: DESIGN: Prospective, controlled, randomized, crossover study. SETTING: Operative intensive care unit of a university hospital. PATIENTS: INTERVENTIONS: Patients were assigned randomly to receive intravenous fat emulsions (0.4 x resting energy expenditure) over 6 hrs (rapid fat infusion) or 24 hrs (slow fat infusion) along with a routine parenteral nutrition regimen, by using a crossover study design. MEASUREMENTS AND MAIN RESULTS: Systemic and pulmonary hemodynamics as well as gas exchange measurements were recorded via respective indwelling catheters. Arterial thromboxane B2 and 6-keto-prostaglandin-F1alpha plasma concentrations were obtained by radioimmunoassay, and 6-keto- prostaglandin-F1alpha/ thromboxane B2 ratios (P/T ratios) were calculated. Data were collected immediately before and 6, 12, 18, and 24 hrs after onset of fat infusion. In the ARDS group, P/T ratio increased by rapid fat infusion. Concomitantly, pulmonary shunt fraction, alveolar-arterial oxygen tension difference [P(a-a)o2]/Pao2, and cardiac index increased as well, whereas pulmonary vascular resistance and Pao2/Fio2 declined. After slow fat infusion, a decreased P/T ratio was revealed. This was accompanied by decreased pulmonary shunt fraction, lowered P(a-a)o2/Pao2, and increased Pao2/Fio2. Correlations between plasma concentrations of 6-keto-prostaglandin-F1alpha or thromboxane B2 and measures of respiratory performance could be shown during rapid and slow fat infusion, respectively. In the sepsis group, the P/T ratio remained unchanged at either infusion rate, but pulmonary shunt fraction and P(a-a)o2/Pao2 decreased after rapid fat infusion, whereas Pao2/Fio2 increased. CONCLUSION: Pulmonary hemodynamics and gas exchange are related to changes of arterial prostanoid levels in ARDS patients, depending on the rate of fat infusion. In ARDS but not in sepsis patients clear of pulmonary organ failure, a changing balance of prostaglandin I2 and thromboxane A2 may modulate gas exchange, presumably via interference with hypoxic pulmonary vasoconstriction.
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Authors | U Suchner, D P Katz, P Fürst, K Beck, T W Felbinger, U Senftleben, M Thiel, A E Goetz, K Peter |
Journal | Critical care medicine
(Crit Care Med)
Vol. 29
Issue 8
Pg. 1569-74
(Aug 2001)
ISSN: 0090-3493 [Print] United States |
PMID | 11505129
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Fat Emulsions, Intravenous
- Thromboxane A2
- Epoprostenol
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Topics |
- APACHE
- Adult
- Cross-Over Studies
- Epoprostenol
(blood)
- Fat Emulsions, Intravenous
(administration & dosage, therapeutic use)
- Female
- Hemodynamics
(drug effects)
- Humans
- Lung
(drug effects, metabolism)
- Male
- Oxygen Consumption
- Respiratory Distress Syndrome
(metabolism, therapy)
- Sepsis
(metabolism, therapy)
- Thromboxane A2
(blood)
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