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Evaluation of the inhibitory activity of topical indomethacin, betamethasone valerate and emollients on UVL-induced inflammation by means of non-invasive measurements of the skin elasticity.

AbstractBACKGROUND/AIM:
Topical indomethacin has been reported to inhibit ultraviolet light-induced erythema. The objective of this study was to verify this assertion and to compare indomethacin 10% ointment to beta-methasone valerate 0.1% ointment, water-in-oil emulsion and oil-in-water emulsion by means of non-invasive skin elasticity measurements.
METHODS:
Products were applied on the back skin 60 min and 5 min before and 5 min after UVL irradiation. Untreated test sites served as controls. Clinical evaluation, measurements of epidermal hydration (Corneometer) and mechanical properties of the skin (Cutometer) were made 1 h before and 24 h after exposure.
RESULTS:
Test areas treated with indomethacin 60 min and 5 min before irradiation showed the significantly lowest visual erythema scores and no significant changes in skin mechanical parameters. At all other test sites, a significant decrease in elasticity parameters (Ue, Ur, Ua/Uf, Ur/Uf) and an increase in viscoelasticity parameters (Uv, Uv/Ue) of the skin were observed. No significant changes of epidermal hydration were found at any of the test sites.
CONCLUSION:
The inhibitory action of topical indomethacin on UVL-induced inflammation is superior to beta-methasone valerate and emollients. Non-invasive measurement of skin elasticity could be used as a supplementary tool for objective evaluation and comparison of the photoprotective activity of different topical agents.
AuthorsH Dobrev
JournalPhotodermatology, photoimmunology & photomedicine (Photodermatol Photoimmunol Photomed) Vol. 17 Issue 4 Pg. 184-8 (Aug 2001) ISSN: 0905-4383 [Print] England
PMID11499541 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Emollients
  • Betamethasone
  • Indomethacin
Topics
  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Betamethasone (therapeutic use)
  • Elasticity (drug effects, radiation effects)
  • Emollients (therapeutic use)
  • Erythema (drug therapy, etiology, prevention & control)
  • Female
  • Humans
  • Indomethacin (therapeutic use)
  • Male
  • Skin (drug effects, radiation effects)
  • Ultraviolet Rays (adverse effects)

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