Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403.

Abstract

The new serine protease inhibitor, ONO-3403 is an analog of FOY-305 (Foypan). The IC50s values of ONO-3403 toward serine proteases, such as trypsin, plasmin, kallikrein and thrombin are much lower than that of FOY-305. To investigate the growth-suppressing effect of ONO-3403 on 3-methylcholanthrene-induced autochthonous solid tumors in mice, ONO-3403 was intraperitoneally administered to mice at a dose of 4 mg/kg twice a day for 5 weeks. All seven mice receiving the drug had a solitary tumor and showed potent growth suppression (p<0.001) without any apparent side effects such as hair loss and body weight loss. The results suggest that ONO-3403 may be useful for the treatment of squamous cell carcinoma.

• Authors: M Ohkoshi, S Okuda
• Journal: Anticancer research (Anticancer Res) 2001 May-Jun Vol. 21 Issue 3B Pg. 1803-8 ISSN: 0250-7005 [Print] Greece
• PMID: 11497262 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzamidines
• Carcinogens
• Enzyme Inhibitors
• ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate
• Allylglycine
• Methylcholanthrene
• Serine Endopeptidases

Topics

• 3T3 Cells
• Allylglycine (analogs & derivatives, pharmacology)
• Animals
• Antineoplastic Agents (pharmacology)
• Benzamidines (pharmacology)
• Carcinogens
• Carcinoma, Squamous Cell (drug therapy)
• Enzyme Inhibitors (pharmacology)
• Female
• Flow Cytometry
• Inhibitory Concentration 50
• Methylcholanthrene
• Mice
• Models, Chemical
• Serine Endopeptidases (metabolism)
• Skin Neoplasms (drug therapy)
• Time Factors