Evolving concepts in epithelial magnesium transport.

Abstract

Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Traditional physiologic approaches have been severely hampered by the lack of a useful radioisotope of magnesium that can be used for tracer flux studies. The present review discusses physiologic insights gained from recent reverse-genetic studies that have identified a plethora of genes involved in inherited renal magnesium wasting syndromes.

• Authors: A S Yu
• Journal: Current opinion in nephrology and hypertension (Curr Opin Nephrol Hypertens) Vol. 10 Issue 5 Pg. 649-53 (Sep 2001) ISSN: 1062-4821 [Print] England
• PMID: 11496060 (Publication Type: Editorial, Review)

Chemical References

• Magnesium

Topics

• Animals
• Biological Transport
• Epithelium (metabolism)
• Genes, Dominant
• Humans
• Kidney (metabolism)
• Loop of Henle (metabolism)
• Magnesium (metabolism)
• Magnesium Deficiency (genetics)
• Nephrology (trends)
• Nephrons (metabolism)