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Comparative seven-day clinical evaluation of two tooth whitening products.

Abstract
A 1-week study was conducted to compare the tooth whitening efficacy of two carbamide peroxide-based products (one containing 5% carbamide peroxide and one containing 10% carbamide peroxide). In addition, the perception of transient tooth hypersensitivity associated with the use of these products was subjectively evaluated. Sixty participants took part in a double-blind, randomized, parallel clinical study. Change in tooth color was measured by chroma meter and Vita shade guide at the initiation of the study and after 7 days of product use. Color change (delta E) was calculated using the color-difference equation established by the Commission Internationale de L'Eclairage. Data concerning dental hypersensitivity was assessed by subjective panelist questionnaires administered after the day 7 recall examination. Results of the whitening data showed that there was no significant difference between the two products. After 1 week, the mean delta E for the product containing 5% carbamide peroxide was 4.43 +/- 1.89 and the mean delta E for the product containing 10% carbamide peroxide was 4.05 +/- 1.84. However, the subjective data collected on tooth hypersensitivity showed that the product containing 5% carbamide peroxide was associated with less discomfort. Of the group using the 5% carbamide peroxide product, 20% reported transient sensitivity of their teeth after product use for 1 week compared with 53% of the group using the product with 10% carbamide peroxide. Statistical analysis using a 2-tailed t test showed significant differences between the two groups (P < .05). The data suggest that these products are clinically equivalent for tooth whitening; however, the product containing 5% carbamide peroxide was associated with less tooth hypersensitivity after 1 week of application.
AuthorsS Nathoo, E Santana 3rd, Y P Zhang, N Lin, M Collins, K Klimpel, W DeVizio, M Giniger
JournalCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (Compend Contin Educ Dent) Vol. 22 Issue 7 Pg. 599-604, 606; quiz 608 (Jul 2001) ISSN: 1548-8578 [Print] United States
PMID11494621 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Combinations
  • Peroxides
  • Carbamide Peroxide
  • Urea
Topics
  • Adult
  • Carbamide Peroxide
  • Dentin Sensitivity (chemically induced)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Combinations
  • Humans
  • Male
  • Middle Aged
  • Patient Satisfaction (statistics & numerical data)
  • Peroxides (administration & dosage, adverse effects)
  • Tooth Bleaching (methods)
  • Tooth Discoloration (therapy)
  • Treatment Outcome
  • Urea (administration & dosage, adverse effects, analogs & derivatives)

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