Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Serum levels of all markers except prostatic acid phosphatase were significantly higher with than without bone metastasis. The median values of each marker increased according to the extent of bone metastasis. Serial ICTP, PICP and PSA in 19 patients with a partial response or no change in bone scans demonstrated a downward trend after treatment, while in 16 with progression they showed an upward trend after treatment. The rate of detecting bone metastasis and progression using ICTP were highest compared with other markers based on the percent clinical effectiveness and receiver operating characteristic curves. CONCLUSIONS: Measuring serum ICTP may be useful for detecting bone metastasis and prostate cancer progression, and may augment PSA and bone scan monitoring of metastatic bone activity.
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Authors | M Noguchi, S Noda |
Journal | The Journal of urology
(J Urol)
Vol. 166
Issue 3
Pg. 1106-10
(Sep 2001)
ISSN: 0022-5347 [Print] United States |
PMID | 11490307
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Collagen Type I
- Peptide Fragments
- Peptides
- Procollagen
- collagen type I trimeric cross-linked peptide
- procollagen type I carboxy terminal peptide
- Collagen
- Alkaline Phosphatase
- Acid Phosphatase
- prostatic acid phosphatase
- Protein Tyrosine Phosphatases
- Prostate-Specific Antigen
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Topics |
- Acid Phosphatase
- Adenocarcinoma
(blood, secondary)
- Aged
- Aged, 80 and over
- Alkaline Phosphatase
(blood)
- Biomarkers, Tumor
(blood)
- Bone Neoplasms
(blood, secondary)
- Collagen
(blood)
- Collagen Type I
- Humans
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Peptides
(blood)
- Procollagen
(blood)
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(blood, pathology)
- Protein Tyrosine Phosphatases
(blood)
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