Abstract | OBJECTIVE: PATIENTS, SUBJECTS AND METHODS: RESULTS: Patients with newly diagnosed prostate cancer and bone metastasis had a higher urinary excretion of DPD, and a higher serum PSA and ALP than had patients with BPH and those with prostate cancer but no metastasis. Receiver operating curve analysis for PSA, ALP and DPD showed a significant discriminating ability for positive and negative bone scans (P = 0.0684). However, from logistic regression of the combinations, only serum ALP was a significant independent predictor of bone metastasis in patients with prostate cancer. CONCLUSION: Serum ALP or urinary DPD are the best predictors of bone metastasis in patients with prostate cancer; further studies with more patients are required.
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Authors | L F Wymenga, K Groenier, J Schuurman, J H Boomsma, R O Elferink, H J Mensink |
Journal | BJU international
(BJU Int)
Vol. 88
Issue 3
Pg. 231-5
(Aug 2001)
ISSN: 1464-4096 [Print] England |
PMID | 11488735
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids
- Biomarkers, Tumor
- deoxypyridinoline
- Alkaline Phosphatase
- Prostate-Specific Antigen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alkaline Phosphatase
(blood)
- Amino Acids
(urine)
- Biomarkers, Tumor
(blood, urine)
- Bone Neoplasms
(diagnosis, secondary)
- Humans
- Male
- Middle Aged
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(urine)
- Sensitivity and Specificity
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