Effects of HSP-117, a novel tachykinin NK1-receptor antagonist, on cisplatin-induced pica as a new evaluation of delayed emesis in rats.

Abstract

The effects of a novel tachykinin NK1-receptor antagonist HSP-117 [(2S,3S)-3-[(5-isopropyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine dihydrochloride] on cisplatin-induced pica, i.e., the eating of nonnutritive substances such as kaolin were examined in rats. HSP-117 inhibited kaolin intake in a dose-dependent manner for 2 days. The 5-HT3-receptor antagonist ondansetron inhibited only on the first day, but not on the second day. These results indicate that the cisplatin-induced kaolin intake on the first day is related to both 5-HT3- and NK1 receptors, while only the NK1 receptor is involved on the second day. Thus, cisplatin-induced continuous pica in rats represents a useful model of not only acute but also delayed emesis.

• Authors: M Saeki, M Sakai, R Saito, H Kubota, H Ariumi, Y Takano, A Yamatodani, H Kamiya
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 86 Issue 3 Pg. 359-62 (Jul 2001) ISSN: 0021-5198 [Print] Japan
• PMID: 11488439 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzofurans
• Neurokinin-1 Receptor Antagonists
• Piperidines
• HSP 117
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (adverse effects)
• Benzofurans (pharmacology)
• Cisplatin (adverse effects)
• Humans
• Neurokinin-1 Receptor Antagonists
• Pica (chemically induced)
• Piperidines (pharmacology)
• Rats
• Rats, Wistar
• Vomiting (chemically induced, prevention & control)