HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effective progenitor cell mobilization in lymphoproliferative disorders using ifosfamide, epirubicin and etoposide (IEV).

Abstract
The combination of ifosfamide, epirubicin and etoposide (IEV) is an effective salvage regimen for lymphoproliferative disease. We report our experience with this combination in mobilization of peripheral blood stem cells (PBSC) in patients with relapsed or refractory/high-risk lymphoma. The median time to leukapheresis was 14 days, with 85% of patients commencing PBSC collection in the range of 13-15 days. Mobilization was successful in 26 of 28 patients (93%), who achieved the minimum transplant dose of 2 x 10(6)/kg CD34+ cells in a median of 2 leukaphereses. Overall, the median CD34+ cell yield was 6.94 x 10(6)/kg (range 0.73-27.4). In 15 of 27 patients (54%), the yield was sufficient (> 6 x 10(6)/kg) to permit CD34+ cell selection and/or a second autograft. IEV was given as an inpatient in all cases. Patients were scheduled for discharge after chemotherapy. This was achieved in 71%, with readmission 1 week later for harvest. Therapy was complicated by neutropenic fever in 13 patients and mild nausea. In autografts carried out using IEV-mobilized PBSC (n = 20), the median time to neutrophils > 0.5 x 10(9)/L was 10 days (range 7-13 days), and to platelets > 20 x 10(9)/L was 13 days (range 11-18 days). There was no mobilization- or transplant-related mortality. We conclude that IEV is a safe, predictable and highly effective mobilization regimen in patients with lymphoma.
AuthorsN O'Connell, N Gardiner, C Duggan, H Enright, M J Kennedy, S R McCann, P A Daly, P V Browne
JournalEuropean journal of haematology. Supplementum (Eur J Haematol Suppl) Vol. 64 Pg. 33-6 (Jul 2001) ISSN: 0902-4506 [Print] England
PMID11486399 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD34
  • Epirubicin
  • Etoposide
  • Ifosfamide
Topics
  • Adolescent
  • Adult
  • Antigens, CD34 (analysis)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use, toxicity)
  • Epirubicin (administration & dosage, toxicity)
  • Etoposide (administration & dosage, toxicity)
  • Female
  • Hematopoietic Stem Cell Mobilization (methods, standards)
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Ifosfamide (administration & dosage, toxicity)
  • Leukapheresis (standards)
  • Lymphoma (complications, drug therapy, therapy)
  • Lymphoproliferative Disorders (complications, drug therapy, therapy)
  • Male
  • Middle Aged
  • Salvage Therapy (methods)
  • Transplantation, Autologous
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: