Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor.

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24)].

• Authors: J A Bridge, M Kanamori, Z Ma, D Pickering, D A Hill, W Lydiatt, M Y Lui, G W Colleoni, C R Antonescu, M Ladanyi, S W Morris
• Journal: The American journal of pathology (Am J Pathol) Vol. 159 Issue 2 Pg. 411-5 (Aug 2001) ISSN: 0002-9440 [Print] United States
• PMID: 11485898 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Clathrin
• Oncogene Proteins, Fusion
• oncoprotein CLTCL-ALK
• ALK protein, human
• Anaplastic Lymphoma Kinase
• Protein-Tyrosine Kinases
• Receptor Protein-Tyrosine Kinases

Topics

• Adult
• Amino Acid Sequence
• Anaplastic Lymphoma Kinase
• Base Sequence
• Child, Preschool
• Chromosome Mapping
• Chromosomes, Human, Pair 2
• Clathrin (genetics)
• Female
• Gene Rearrangement
• Granuloma, Plasma Cell (genetics, pathology)
• Head and Neck Neoplasms (genetics, pathology)
• Humans
• In Situ Hybridization, Fluorescence
• Karyotyping
• Male
• Oncogene Proteins, Fusion (genetics)
• Pelvic Neoplasms (genetics, pathology)
• Protein-Tyrosine Kinases (genetics)
• Receptor Protein-Tyrosine Kinases (genetics)
• Reverse Transcriptase Polymerase Chain Reaction