Abstract |
The protective efficacy of toxoids prepared from crude cytotoxin ( polymyxin-B extract, PBE) and purified Klebsiella cytotoxins (KCTs) was studied in rabbits and mice. The toxoids of KCT-I and PBE were found to be protective against homologous as well as heterologous Klebsiella challenges, while toxoids of KCT-II and KCT-III afforded protection in mice against homologous Klebsiella infections. KCT-I and PBE toxoids also induced good humoral anti-Klebsiella response in rabbits with ELISA titres ranging from 20480 to 81480. Immunized female rabbits passed protective anti-Klebsiella immunoglobulins to their offsprings through colostra. Baby rabbits fed on colostrum of immunized rabbits withstood lethal Klebsiella infection up to 1 month of age, but not on the 50th day. Baby rabbits having an anti-Klebsiella IgG titre > or =1280 were fully protected against lethal dose of Klebsiella. The study revealed a significant protective efficacy of KCT-I and PBE toxoids against klebsiellosis in mice and rabbits.
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Authors | B R Singh, V D Sharma |
Journal | Vaccine
(Vaccine)
Vol. 19
Issue 31
Pg. 4505-10
(Aug 14 2001)
ISSN: 0264-410X [Print] Netherlands |
PMID | 11483277
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Bacterial Vaccines
- Cytotoxins
- Toxoids
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Topics |
- Animals
- Antibodies, Bacterial
(biosynthesis)
- Bacterial Vaccines
(therapeutic use)
- Cytotoxins
(therapeutic use)
- Female
- Immunization Schedule
- Klebsiella Infections
(prevention & control, veterinary)
- Klebsiella pneumoniae
(immunology, pathogenicity)
- Mice
- Rabbits
- Toxoids
(therapeutic use)
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