Abstract |
Atopic dermatitis, common among infants and children, is an intensely pruritic, chronic, inflammatory dermatosis that is traditionally treated with emollients for dry skin and topical corticosteroids for inflamed areas. A multicenter, 3-week, open-label study evaluated prednicarbate emollient cream 0.1%, a nonhalogenated midpotency corticosteroid, in 55 patients aged 4 months to 12 years who were diagnosed with atopic dermatitis. No suppression of the hypothalamic-pituitary-adrenal (HPA) axis was evidenced by serum cortisol levels obtained before and after intravenous injection of 250 mg of cosyntropin on days 1 and 22, and biochemical tests detected no other systemic effects. Adverse events were few and within the expected range. Prednicarbate resulted in improvements based on global evaluations and sign/symptom scores. In conclusion, this study found prednicarbate emollient cream 0.1% to be safe and effective for the treatment of atopic dermatitis in pediatric patients for up to 3 weeks.
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Authors | T Moshang |
Journal | Cutis
(Cutis)
Vol. 68
Issue 1
Pg. 63-9
(Jul 2001)
ISSN: 0011-4162 [Print] United States |
PMID | 11480151
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Glucocorticoids
- Ointments
- Prednisolone
- prednicarbate
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Topics |
- Administration, Topical
- Adolescent
- Anti-Inflammatory Agents
(administration & dosage)
- Child
- Child, Preschool
- Dermatitis, Atopic
(drug therapy)
- Glucocorticoids
- Humans
- Infant
- Ointments
(administration & dosage)
- Prednisolone
(administration & dosage, analogs & derivatives)
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