Abstract |
Suramins and suradistas, an important group of potential anti- cancer agents, inhibit fibroblast growth factor (FGF) mitogenic activity. It has been shown that naphthalenesulfonates, with a common chemical function to the family of suramins and suradistas, mimic their inhibitory activity, abolishing FGF-induced angiogenesis in vivo, and inducing apoptosis of C6 glioma cells in culture. In the present report, we show that intratumoral administration of 1-naphthalenemonosulfonate induces a considerable regression of gliomas in rats, significantly enhances apoptosis, and attenuates tumor angiogenesis. These findings may lead to new approaches for the treatment of glioblastoma, a most common primary malignant brain tumor of very poor prognosis, as well as of other angiogenesis-dependent malignancies.
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Authors | P Cuevas, F Carceller, D Diaz, D Reimers, M Fernández, R M Lozano, R González-Corrochano, G Giménez-Gallego |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 308
Issue 3
Pg. 185-8
(Aug 10 2001)
ISSN: 0304-3940 [Print] Ireland |
PMID | 11479019
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Antineoplastic Agents
- Naphthalenesulfonates
- 1-naphthalenesulfonic acid
- Fibroblast Growth Factors
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Topics |
- Angiogenesis Inhibitors
(pharmacology)
- Animals
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Brain Neoplasms
(drug therapy)
- Fibroblast Growth Factors
(physiology)
- Glioma
(drug therapy)
- In Situ Nick-End Labeling
- Naphthalenesulfonates
(pharmacology)
- Neoplasm Transplantation
- Neovascularization, Pathologic
(drug therapy, physiopathology)
- Rats
- Rats, Sprague-Dawley
- Tumor Cells, Cultured
(transplantation)
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