Asymmetry: molecular, biologic, embryopathic, and clinical perspectives.

Abstract

This overview of asymmetry addresses the following topics: chiral molecules; asymmetric signaling molecules, including N-cadherin, Shh, Fgf8, lefty1, lefty2, nodal, Pitx2, activin betaB, activin receptor IIA, and cSnR; situs abnormalities; asymmetric cell division; laterality in humans and animals; behavioral asymmetry in humans and animals; asymmetric embryopathies, including Tessier-type "clefts"; hemiasymmetries such as hemihyperplasia, hemihypoplasia, and hemiatrophy; asymmetric vascular syndromes, including Klippel-Trenaunay and Sturge-Weber syndromes; plagiocephaly of the synostotic and deformational types; somatic mosaicism, including a discussion of McCune-Albright syndrome, fibrous dysplasia, GNAS1 mutations, and Proteus syndrome.

• Authors: M M Cohen Jr
• Journal: American journal of medical genetics (Am J Med Genet) Vol. 101 Issue 4 Pg. 292-314 (Jul 15 2001) ISSN: 0148-7299 [Print] United States
• PMID: 11471152 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Topics

• Animals
• Body Patterning (genetics)
• Cell Division (genetics)
• Congenital Abnormalities (embryology, genetics, pathology)
• Eye Abnormalities (embryology, genetics, pathology)
• Gene Expression Regulation
• Humans