Abstract | OBJECTIVES: METHODS: Eight patients with nonresectable bile duct cancer were treated. Forty-eight hours after i. v. application of 2 mg/kg body weight of Photosan-3, light activation was performed by a transpapillary (four patients) or percutaneus (four patients) access. We used a cylindrical diffusor tip and illuminated using a wavelength of 633+/-3 nm and a total energy of 200 J/cm2. All patients were additionally provided with bile duct endoprostheses after PDT. RESULTS: Four weeks after initial PDT all patients showed a marked reduction of bile duct stenosis. The median serum bilirubin value declined from 5.8 mg/dl (2.0-10.1) to 1.0 mg/dl (0.8-4.4). The median survival time at the time of writing is 119 days (52-443). Five patients are still alive. In four patients we could change from percutaneous to transpapillary drainage after PDT, two patients showed infectious complications. CONCLUSION:
PDT with the diode laser system seems to be effective in reducing malignant bile duct stenosis. This treatment is minimally invasive and has a low specific complication rate. Randomized, controlled studies comparing PDT with the insertion of endoprostheses and long term follow-up of results are needed to confirm the promising short term results.
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Authors | T Zoepf, R Jakobs, J C Arnold, D Apel, A Rosenbaum, J F Riemann |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 96
Issue 7
Pg. 2093-7
(Jul 2001)
ISSN: 0002-9270 [Print] United States |
PMID | 11467637
(Publication Type: Case Reports, Clinical Trial, Journal Article)
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Topics |
- Aged
- Bile Duct Neoplasms
(complications, drug therapy, mortality)
- Cholangiography
- Cholestasis
(diagnostic imaging, drug therapy, etiology)
- Female
- Follow-Up Studies
- Humans
- Laser Therapy
- Male
- Middle Aged
- Palliative Care
(methods)
- Photochemotherapy
(methods)
- Pilot Projects
- Quality of Life
- Survival Rate
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