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Environmental monitoring using acetylcholinesterase inhibition in vitro. A case study in two Mexican lagoons.

Abstract
Cholinesterase inhibition is considered a specific biomarker of exposure and effect for organophosphorous pesticides. Its use for monitoring has been hindered, particularly in tropical countries where organophosphates are widely used for malaria and dengue control, because of the frequent lack of suitable controls. An in vitro technique is proposed as a biochemical method for monitoring pollutant mixtures in sediment toxicity tests. Brain homogenate from the fish Oreochromis niloticus is used as the enzyme source. Optimum incubation time, extraction solvent and effect of crude oil on acetylcholinesterase (AChE) are reported. The method described was used in sediments from two Mexican lagoons, located in an oil extraction area where pesticides are used in agriculture and vector control campaigns. AChE inhibitions from 3 to 21% were found in these lagoons, even in the presence of high concentrations of petroleum.
AuthorsG Rodríguez-Fuentes, G Gold-Bouchot
JournalMarine environmental research (Mar Environ Res) 2000 Jul-Dec Vol. 50 Issue 1-5 Pg. 357-60 ISSN: 0141-1136 [Print] England
PMID11460718 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cholinesterase Inhibitors
  • Soil Pollutants
  • Water Pollutants, Chemical
  • Acetylcholinesterase
Topics
  • Acetylcholinesterase (metabolism)
  • Animals
  • Aquaculture
  • Brain (enzymology)
  • Cholinesterase Inhibitors (toxicity)
  • Environmental Monitoring (methods)
  • Fresh Water
  • Geologic Sediments
  • In Vitro Techniques
  • Mexico
  • Soil Pollutants (toxicity)
  • Tilapia (metabolism)
  • Water Pollutants, Chemical (toxicity)

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