Non-invasive studies of glycogen metabolism in human skeletal muscle using nuclear magnetic resonance spectroscopy.

Abstract

Nuclear magnetic resonance spectroscopy provides non-invasive and real-time assessment of the metabolic fluxes in skeletal muscle during exercise, recovery from exercise and stimulation by insulin. Carbon-13 nuclear magnetic resonance spectroscopy has proved that reduced glycogen synthesis is a consistent feature of insulin-resistant type 2 diabetic patients, their offspring, and obesity. Low intracellular glucose and glucose-6-phosphate concentrations indicate that decreased glucose transport is mainly responsible for common insulin resistance. An elevation of plasma free fatty acids causes similar alterations of muscle glucose metabolism, and could play a central role in the development of impaired muscle glucose transport associated with insulin resistance.

• Authors: M Roden
• Journal: Current opinion in clinical nutrition and metabolic care (Curr Opin Clin Nutr Metab Care) Vol. 4 Issue 4 Pg. 261-6 (Jul 2001) ISSN: 1363-1950 [Print] England
• PMID: 11458018 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Carbon Isotopes
• Fatty Acids, Nonesterified
• Insulin
• Glycogen
• Glucose

Topics

• Carbon Isotopes
• Diabetes Mellitus, Type 2 (metabolism)
• Exercise (physiology)
• Fatty Acids, Nonesterified (blood)
• Glucose (metabolism)
• Glycogen (biosynthesis, metabolism)
• Humans
• Insulin (metabolism)
• Insulin Resistance
• Magnetic Resonance Spectroscopy (methods)
• Muscle, Skeletal (metabolism)
• Obesity (metabolism)