Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: a potential tumor photosensitizer.

Abstract

The synthesis, photophysical properties of diphenyl-2,3-dihydroxychlorin (DPCOH) and its photocytotoxicity to tumor cells are described. DPCOH exhibits photodynamic activity in terms of type I and type II mechanisms under irradiation. The quantum yield of (1)O(2) in CHCl(3) is 0.7. For the photocytotoxicity to tumor cells, DPCOH proved to be 200 times more potent than HPD, and the dark toxicity is low (dark IC(90)>32 microg/mL).

• Authors: T Y Wang, H L Liu, J R Chen, F G Liu, Y Gu, J S Ma
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 11 Issue 15 Pg. 2049-52 (Aug 06 2001) ISSN: 0960-894X [Print] England
• PMID: 11454478 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biphenyl Compounds
• Photosensitizing Agents
• Porphyrins
• diphenyl-2,3-dihydroxychlorin
• chlorin

Topics

• Biphenyl Compounds (chemical synthesis, pharmacology)
• Electron Spin Resonance Spectroscopy
• Humans
• Lighting
• Photochemotherapy
• Photosensitizing Agents (chemical synthesis, pharmacology)
• Porphyrins (chemical synthesis, chemistry, pharmacology)
• Tumor Cells, Cultured (drug effects)