Abstract | OBJECTIVES: DESIGN: Systematic review of randomised controlled trials. STUDIES: 15 randomised controlled trials including 2397 randomised patients. OUTCOMES: RESULTS: In a meta-analysis of nine trials for the primary outcome, reduced osmolarity rehydration solution was associated with fewer unscheduled intravenous infusions compared with standard WHO rehydration solution (odds ratio 0.61, 95% confidence interval 0.47 to 0.81). Three trials reported that no patients required unscheduled intravenous infusion. Trials reporting secondary outcomes suggested that in the reduced osmolarity rehydration solution group, stool output was lower (standardised mean difference in the log scale -0.214 (95% confidence interval -0.305 to -0.123; 13 trials) and vomiting was less frequent (odds ratio 0.71, 0.55 to 0.92; six trials). Six trials sought presence of hyponatraemia, with events in three studies, but no significant difference between the two arms. CONCLUSION:
|
Authors | S Hahn, Y Kim, P Garner |
Journal | BMJ (Clinical research ed.)
(BMJ)
Vol. 323
Issue 7304
Pg. 81-5
(Jul 14 2001)
ISSN: 0959-8138 [Print] England |
PMID | 11451782
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Chemical References |
- Bicarbonates
- Rehydration Solutions
- World Health Organization oral rehydration solution
- Sodium Chloride
- Potassium Chloride
- Glucose
|
Topics |
- Administration, Oral
- Bicarbonates
(therapeutic use)
- Child, Preschool
- Cholera
(complications)
- Dehydration
(etiology, therapy)
- Diarrhea
(complications)
- Fluid Therapy
(methods)
- Glucose
(therapeutic use)
- Humans
- Infant
- Infusions, Intravenous
- Osmolar Concentration
- Potassium Chloride
(therapeutic use)
- Rehydration Solutions
(chemistry, therapeutic use)
- Sodium Chloride
(therapeutic use)
- Treatment Outcome
|